Alterations in the regulation of gene expression are frequently associated with
developmental diseases or cancer. Transcription activation is a key phenomenon in the …

Systemic acquired resistance (SAR) is an induced immune mechanism in plants. Unlike
vertebrate adaptive immunity, SAR is broad spectrum, with no specificity to the initial …

Mediator is a conserved coactivator complex that enables the regulated initiation of
transcription at eukaryotic genes,–. Mediator is recruited by transcriptional activators and …

The prevailing view of metazoan gene regulation is that transcription is facilitated through
the formation of static activator complexes at distal regulatory regions. Here, we employed …

The Mediator is an evolutionarily conserved, multiprotein complex that is a key regulator of
protein-coding genes. In metazoan cells, multiple pathways that are responsible for …

The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …

In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

Here we review recent advances in understanding the regulation of mRNA synthesis in
Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been …

Mediator was discovered because of its activity in a yeast RNA polymerase II (pol II)
transcription system–it is needed for the system to respond to a transcriptional activator …

The transition between transcriptional initiation and elongation by RNA polymerase (Pol) II is
associated with phosphorylation of its C-terminal tail (CTD). Depletion of Kin28, the TFIIH …