The tooth provides an excellent system for deciphering the molecular mechanisms of
organogenesis, and has thus been of longstanding interest to developmental and stem cell …

Teeth play essential roles in life. Their development relies on reciprocal interactions
between the ectoderm-derived dental epithelium and the underlying neural crest-originated …

Tissue folding is a fundamental process that shapes epithelia into complex 3D organs. The
initial positioning of folds is the foundation for the emergence of correct tissue morphology …

Tissue morphogenesis occurs in a complex physicochemical microenvironment with limited
experimental accessibility. This often prevents a clear identification of the processes that …

Synthetic biology efforts began in simple single-cell systems, which were relatively easy to
manipulate genetically (Cameron et al., 2014). The field grew exponentially in the last two …

Development has often been viewed as a constraining force on morphological adaptation,
but its precise influence, especially on evolutionary rates, is poorly understood. Placental …

Tooth formation requires complex signaling interactions both within the oral epithelium and
between the epithelium and the underlying mesenchyme. Previous studies of the Wnt/β …

During embryonic development, organs undergo distinct and programmed morphological
changes as they develop into their functional forms. While genetics and biochemical signals …

Developmental complexity stemming from the dynamic interplay between genetic and
biomechanic factors canalizes the ways genotypes and phenotypes can change in …

How does morphological complexity evolve? This study suggests that the likelihood of
mutations increasing phenotypic complexity becomes smaller when the phenotype itself is …