There is a growing recognition that gliomas are complex tumors composed of neoplastic and
non-neoplastic cells, which each individually contribute to cancer formation, progression …

We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

Tumor-associated macrophages (TAMs) represent an important cellular subset within the
glioblastoma (WHO grade IV) microenvironment and are a potential therapeutic target. TAMs …

CNS immune defenses are marshaled and dominated by brain resident macrophages and
microglia, which are the innate immune sentinels and frontline host immune barriers against …

Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …

Glioma is the most malignant primary tumor of the central nervous system and is
characterized by an extremely low overall survival. Recent breakthroughs in cancer therapy …

High-grade gliomas are rapidly progressing tumors of the central nervous system (CNS) with
a very poor prognosis despite extensive resection combined with radiation and/or …

In amyotrophic lateral sclerosis (ALS), immune cells and glia contribute to motor neuron
(MN) degeneration. We report the presence of NK cells in post-mortem ALS motor cortex …

Glioblastoma is the most common and most malignant primary adult human brain tumour.
Diagnosis of glioblastoma carries a dismal prognosis. Treatment resistance and tumour …

The mechanisms of communication between the brain and the immune cells are still largely
unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate …