Embryonic cells grow in environments that provide a plethora of physical cues, including
mechanical forces that shape the development of the entire embryo. Despite their …

The function of normal and defective candidate genes for human genetic diseases, which
are rapidly being identified in large numbers by human geneticists and the biomedical …

Tissue morphogenesis is driven by mechanical forces that elicit changes in cell size, shape
and motion. The extent by which forces deform tissues critically depends on the rheological …

Tissue morphogenesis in multicellular organisms is brought about by spatiotemporal
coordination of mechanical and chemical signals. Extensive work on how mechanical forces …

The emergence of collagen I in vertebrates resulted in a dramatic increase in the stiffness of
the extracellular environment, supporting long-range force propagation and the …

Increasing evidence demonstrates that mechanical forces, in addition to soluble molecules,
impact cell and tissue functions in physiology and diseases. How living cells integrate …

Convergent extension is a fundamental morphogenetic process that underlies not only the
generation of the elongated vertebrate body plan from the initially radially symmetrical …

During vertebrate development, cells must proliferate, move, and differentiate to form
complex shapes. Elucidating the mechanisms underlying the molecular and cellular …

The morphology of gastrulation driving the internalization of the mesoderm and endoderm
differs markedly among vertebrate species. It ranges from involution of epithelial sheets of …

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