Genetic modification therapy is a promising therapeutic strategy for many diseases of the
lung intractable to other treatments. Lung gene therapy has been the subject of numerous …

Alpha-1 antitrypsin (AAT) deficiency, characterized by low plasma levels of the serine
protease inhibitor AAT, is associated with emphysema secondary to insufficient protection of …

Alpha-1 antitrypsin deficiency is a monogenic disorder resulting in emphysema due
principally to the unopposed effects of neutrophil elastase. We previously reported achieving …

Many microorganisms growing on water-insoluble substrates have been known to produce
surface-active compounds called biosurfactants. Although biosurfactants have received …

The transfection efficacy of several vectors containing the full genomic hAAT gene with its
natural promoter (pTG7101) and others containing the cDNA of hAAT gene driven by …

Cationic lipids are widely used for gene transfer in vitro and show promise as vectors for in
vivo gene therapy applications. However, there is limited understanding of the cellular …

Hydrodynamic gene delivery has proven to be a safe and efficient procedure for gene
transfer, able to mediate, in murine model, therapeutic levels of proteins encoded by the …

Despite remarkable progress in the research of both viral and nonviral gene delivery
vectors, the drawbacks in each delivery system have limited their clinical applications …

Gene therapy has emerged as a powerful and very plastic tool to regulate biological
functions in diseased tissues with application in virtually all medical fields. An increasing …

The development of nonviral vectors for in vivo gene delivery to hepatocytes is an interesting
topic in view of their safety and tremendous gene therapy potential. Since cationic liposomes …