Portrait of a Pathogen: The Mycobacterium tuberculosis Proteome In Vivo

NA Kruh, J Troudt, A Izzo, J Prenni, KM Dobos - PloS one, 2010 - journals.plos.org
Background Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a
facultative intracellular pathogen that can persist within the host. The bacteria are thought to …

Detection of Mycobacterium tuberculosis Peptides in the Exosomes of Patients with Active and Latent M. tuberculosis Infection Using MRM-MS

NA Kruh-Garcia, LM Wolfe, LH Chaisson… - PloS one, 2014 - journals.plos.org
The identification of easily measured, accurate diagnostic biomarkers for active tuberculosis
(TB) will have a significant impact on global TB control efforts. Because of the host and …

Proteomic Definition of the Cell Wall of Mycobacterium tuberculosis

LM Wolfe, SB Mahaffey, NA Kruh… - Journal of proteome …, 2010 - ACS Publications
The cell envelope of Mycobacterium tuberculosis (Mtb) is complex and diverse; composed of
proteins intermingled in a matrix of peptidoglycan, mycolic acids, lipids, and carbohydrates …

Upregulation of the Phthiocerol Dimycocerosate Biosynthetic Pathway by Rifampin-Resistant, rpoB Mutant Mycobacterium tuberculosis

GP Bisson, C Mehaffy, C Broeckling, J Prenni… - Journal of …, 2012 - Am Soc Microbiol
Multidrug-resistant tuberculosis has emerged as a major threat to tuberculosis control.
Phylogenetically related rifampin-resistant actinomycetes with mutations mapping to …

Recent insights into Mycobacterium tuberculosis through proteomics and implications for the clinic

D Bisht, D Sharma, D Sharma, R Singh… - Expert Review of …, 2019 - Taylor & Francis
Introduction: This review aimed at providing an update on the application of proteomics-
based approaches to gain recent insights of Mycobacterium tuberculosis (M. tb) and its …

Tuberculosis: global approaches to a global disease

DE Kirschner, D Young, JAL Flynn - Current opinion in biotechnology, 2010 - Elsevier
Mycobacterium tuberculosis is a remarkably successful human pathogen. The interaction
with the human host is complex and much remains unknown. Recent advances in systems …

Modification of the head proteome of nurse honeybees (Apis mellifera) exposed to field-relevant doses of pesticides

R Zaluski, AC Bittarello, JCS Vieira, CP Braga… - Scientific reports, 2020 - nature.com
Understanding the effect of pesticides on the survival of honeybee colonies is important
because these pollinators are reportedly declining globally. In the present study, we …

Second generation multiple reaction monitoring assays for enhanced detection of ultra-low abundance Mycobacterium tuberculosis peptides in human serum

C Mehaffy, KM Dobos, P Nahid, NA Kruh-Garcia - Clinical proteomics, 2017 - Springer
Abstract Background Mycobacterium tuberculosis (Mtb) is the causative agent of
Tuberculosis (TB), the number one cause of death due to an infectious disease. TB …

Characterization of the Mycobacterium tuberculosis Proteome by Liquid Chromatography Mass Spectrometry-based Proteomics Techniques: A Comprehensive …

C Bell, GT Smith, MJ Sweredoski… - Journal of proteome …, 2012 - ACS Publications
Approximately, one-third of the world's population is infected with Mycobacterium
tuberculosis, the causative agent of Tuberculosis. Secreted and membrane proteins that …

Deciphering the proteome of the in vivo diagnostic reagent “purified protein derivative” from Mycobacterium tuberculosis

YS Cho, KM Dobos, J Prenni, H Yang, A Hess… - …, 2012 - Wiley Online Library
Purified protein derivative (PPD) has served as a safe and effective diagnostic reagent for 60
years and is the only broadly available material to diagnose latent tuberculosis infections …