The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities

X He, Y Li, B Deng, A Lin, G Zhang, M Ma… - Cell …, 2022 - Wiley Online Library
Abstract Objects Traumatic spinal cord injury (TSCI) causes neurological dysfunction below
the injured segment of the spinal cord, which significantly impacts the quality of life in …

MicroRNA-based therapeutics in central nervous system injuries

P Sun, DZ Liu, GC Jickling… - Journal of Cerebral …, 2018 - journals.sagepub.com
Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …

[HTML][HTML] Recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications

Z Sun, D Zhu, H Zhao, J Liu, P He, X Luan, H Hu… - Journal of …, 2023 - Springer
Functional hydrogels show potential application in repairing spinal cord injury (SCI) due to
their unique chemical, physical, and biological properties and functions. In this …

[HTML][HTML] The role of PI3K/Akt signalling pathway in spinal cord injury

CL Xiao, WC Yin, YC Zhong, JQ Luo, LL Liu… - Biomedicine & …, 2022 - Elsevier
Spinal cord injury (SCI) is a severely disabling central nervous system injury with complex
pathological mechanisms that leads to sensory and motor dysfunction. The current treatment …

Rat bone mesenchymal stem cell‐derived exosomes loaded with miR‐494 promoting neurofilament regeneration and behavioral function recovery after spinal cord …

W Huang, M Lin, C Yang, F Wang… - Oxidative medicine …, 2021 - Wiley Online Library
Exosomes (Exo) exhibit numerous advantages (eg, good encapsulation, high targeting
efficiency, and easy to penetrate the blood‐brain barrier to the central nervous system) …

[HTML][HTML] MicroRNA-182 improves spinal cord injury in mice by modulating apoptosis and the inflammatory response via IKKβ/NF-κB

M Fei, Z Li, Y Cao, C Jiang, H Lin, Z Chen - Laboratory investigation, 2021 - Elsevier
Spinal cord injury (SCI) is one common neurological condition which involves primary injury
and secondary injury. Neuron inflammation and apoptosis after SCI is the most important …

[HTML][HTML] Gypenoside XVII protects against spinal cord injury in mice by regulating the microRNA‑21‑mediated PTEN/AKT/mTOR pathway

T Sun, L Duan, J Li, H Guo… - … Journal of Molecular …, 2021 - spandidos-publications.com
Abstract Gypenoside XVII (GP‑17), one of the dominant active components of Gynostemma
pentaphyllum, has been studied extensively and found to have a variety of pharmacological …

Targeted therapy of spinal cord injury: inhibition of apoptosis is a promising therapeutic strategy

W He, Z Li, H Gu, Q Pan, F Lin - Molecular Neurobiology, 2024 - Springer
Spinal cord injury (SCI) is a serious disabling central nervous system injury that can lead to
motor, sensory, and autonomic dysfunction below the injury level. SCI can be divided into …

[HTML][HTML] MicroRNA-362-3p attenuates motor deficit following spinal cord injury via targeting paired box gene 2

Y Hu, Q Liu, M Zhang, Y Yan, H Yu… - Journal of integrative …, 2019 - imrpress.com
Spinal cord injury is a disabling disorder, leading to neurological impairments. Although
some microRNAs have been reported to be associated with spinal cord injury, the function of …

[HTML][HTML] Catalpol protects against spinal cord injury in mice through regulating microRNA-142-mediated HMGB1/TLR4/NF-κB signaling pathway

H Xia, D Wang, X Guo, K Wu, F Huang… - Frontiers in …, 2021 - frontiersin.org
Background: Spinal cord injury (SCI) is a devastating condition that leads to paralysis,
disability and even death in severe cases. Inflammation, apoptosis and oxidative stress in …