[HTML][HTML] Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain

M Miranda, JF Morici, MB Zanoni… - Frontiers in cellular …, 2019 - frontiersin.org
Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes
related to learning and memory. The expression of BDNF is highly regulated, and can lead …

Role of inactivity in chronic diseases: evolutionary insight and pathophysiological mechanisms

FW Booth, CK Roberts, JP Thyfault… - Physiological …, 2017 - journals.physiology.org
This review proposes that physical inactivity could be considered a behavior selected by
evolution for resting, and also selected to be reinforcing in life-threatening situations in …

Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: A meta-analysis

EGAE Karssemeijer, JAJ Aaronson, WJW Bossers… - Ageing research …, 2017 - Elsevier
Combined cognitive and physical exercise interventions have potential to elicit cognitive
benefits in older adults with mild cognitive impairment (MCI) or dementia. This meta-analysis …

Mitochondrial ROS signaling in organismal homeostasis

GS Shadel, TL Horvath - Cell, 2015 - cell.com
Generation, transformation, and utilization of organic molecules in support of cellular
differentiation, growth, and maintenance are basic tenets that define life. In eukaryotes …

Exercise and mitochondrial health

JM Memme, AT Erlich, G Phukan… - The Journal of …, 2021 - Wiley Online Library
Mitochondrial health is an important mediator of cellular function across a range of tissues,
and as a result contributes to whole‐body vitality in health and disease. Our understanding …

PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders

S Jamwal, JK Blackburn, JD Elsworth - Pharmacology & Therapeutics, 2021 - Elsevier
Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …

Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms

RC Cassilhas, KS Lee, J Fernandes, MGM Oliveira… - Neuroscience, 2012 - Elsevier
A growing body of scientific evidence indicates that exercise has a positive impact on human
health, including neurological health. Aerobic exercise, which is supposed to enhance …

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance

SM Raefsky, MP Mattson - Free Radical Biology and Medicine, 2017 - Elsevier
An important concept in neurobiology is “neurons that fire together, wire together” which
means that the formation and maintenance of synapses is promoted by activation of those …

Neurogenesis, inflammation and behavior

RA Kohman, JS Rhodes - Brain, behavior, and immunity, 2013 - Elsevier
Before the 1990s it was widely believed that the adult brain was incapable of regenerating
neurons. However, it is now established that new neurons are continuously produced in the …

Biological mechanisms of physical activity in preventing cognitive decline

I Lista, G Sorrentino - Cellular and molecular neurobiology, 2010 - Springer
In order to guarantee better conditions for competition, the nervous system has developed
not only mechanisms controlling muscle effectors, but also retrograde systems that, starting …