Multiple type I interferons and interferon-γ (IFN-γ) are expressed under physiological
conditions and are increased by stress and infections, and in autoinflammatory and …

The past decade in rheumatology has seen tremendous innovation in digital health
technologies, including the electronic health record, virtual visits, mobile health, wearable …

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing …

There is a current imperative to unravel the hierarchy of molecular pathways that drive the
transition of early to established disease in rheumatoid arthritis (RA). Herein, we report a …

In the past decade, the emergence of machine learning (ML) applications has led to
significant advances towards implementation of personalised medicine approaches for …

Objectives To unravel the hierarchy of cellular/molecular pathways in the disease tissue of
early, treatment-naïve rheumatoid arthritis (RA) patients and determine their relationship …

Autoimmune diseases are chronic, multifactorial conditions. Through machine learning (ML),
a branch of the wider field of artificial intelligence, it is possible to extract patterns within …

Tissue macrophages (Mϕ) are essential effector cells in rheumatoid arthritis (RA),
contributing to autoimmune tissue inflammation through diverse effector functions. Their …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting joints and
causing progressive damage and disability. Macrophages are of critical importance in the …

Systemic autoimmune rheumatic diseases (SARDs) exhibit extensive heterogeneity in
clinical presentation, disease course, and treatment response. Therefore, precision …