Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related
(ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression …

Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …

Autophagy is an evolutionarily conserved process across eukaryotes that degrades cargoes
like aggregate-prone proteins, pathogens, damaged organelles and macromolecules via …

Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …

Autophagy is a major degradation pathway that utilizes lysosome hydrolases to degrade
cellular constituents and is often induced under cellular stress conditions to restore cell …

Mounting evidence suggests that autophagy is a more selective process than originally
anticipated. The discovery and characterization of autophagic adapters, like p62 and NBR1 …

Mechanisms by which autophagy promotes cell survival or death are unclear. We provide
evidence that C18-pyridinium ceramide treatment or endogenous C18-ceramide generation …

Protein degradation by basal constitutive autophagy is important to avoid accumulation of
polyubiquitinated protein aggregates and development of neurodegenerative diseases. The …

Autophagy is a fundamental catabolic process that uses a unique post-translational
modification, the conjugation of ATG8 protein to phosphatidylethanolamine (PE). ATG8 …

Autophagy-related (Atg) proteins are eukaryotic factors participating in various stages of the
autophagic process. Thus far 34 Atgs have been identified in yeast, including the key …