The biofilm matrix: multitasking in a shared space

HC Flemming, ED van Hullebusch, TR Neu… - Nature Reviews …, 2023 - nature.com
The biofilm matrix can be considered to be a shared space for the encased microbial cells,
comprising a wide variety of extracellular polymeric substances (EPS), such as …

Staphylococcal biofilm development: structure, regulation, and treatment strategies

K Schilcher, AR Horswill - Microbiology and Molecular Biology …, 2020 - Am Soc Microbiol
In many natural and clinical settings, bacteria are associated with some type of biotic or
abiotic surface that enables them to form biofilms, a multicellular lifestyle with bacteria …

Staphylococcus aureus biofilm: a complex developmental organism

DE Moormeier, KW Bayles - Molecular microbiology, 2017 - Wiley Online Library
Chronic biofilm‐associated infections caused by Staphylococcus aureus often lead to
significant increases in morbidity and mortality, particularly when associated with indwelling …

Propidium iodide staining underestimates viability of adherent bacterial cells

M Rosenberg, NF Azevedo, A Ivask - Scientific reports, 2019 - nature.com
Combining membrane impermeable DNA-binding stain propidium iodide (PI) with
membrane-permeable DNA-binding counterstains is a widely used approach for bacterial …

Secretory products of the human GI tract microbiome and their potential impact on Alzheimer's disease (AD): detection of lipopolysaccharide (LPS) in AD hippocampus

Y Zhao, V Jaber, WJ Lukiw - Frontiers in cellular and infection …, 2017 - frontiersin.org
Although the potential contribution of the human gastrointestinal (GI) tract microbiome to
human health, aging, and disease is becoming increasingly acknowledged, the molecular …

[HTML][HTML] Extracellular polymeric substances, a key element in understanding biofilm phenotype

P Di Martino - AIMS microbiology, 2018 - ncbi.nlm.nih.gov
One of the key elements in the establishment and maintenance of the biofilm structure and
properties is the extracellular matrix. The extracellular matrix is composed of water and …

Extracellular DNA (eDNA). A major ubiquitous element of the bacterial biofilm architecture

D Campoccia, L Montanaro, CR Arciola - International Journal of …, 2021 - mdpi.com
After the first ancient studies on microbial slime (the name by which the biofilm matrix was
initially indicated), multitudes of studies on the morphology, composition and physiology of …

The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril

E Tayeb-Fligelman, O Tabachnikov, A Moshe… - Science, 2017 - science.org
Amyloids are ordered protein aggregates, found in all kingdoms of life, and are involved in
aggregation diseases as well as in physiological activities. In microbes, functional amyloids …

Extracellular DNA in natural environments: features, relevance and applications

M Nagler, H Insam, G Pietramellara… - Applied microbiology and …, 2018 - Springer
Extracellular DNA (exDNA) is abundant in many habitats, including soil, sediments, oceans
and freshwater as well as the intercellular milieu of metazoa. For a long time, its origin has …

The role of extracellular DNA in the formation, architecture, stability, and treatment of bacterial biofilms

H Panlilio, CV Rice - Biotechnology and bioengineering, 2021 - Wiley Online Library
Advances in biotechnology to treat and cure human disease have markedly improved
human health and the development of modern societies. However, substantial challenges …