Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …

Background Reducing high blood cholesterol, a risk factor for cardiovascular disease (CVD)
events in people with and without a past history of coronary heart disease (CHD) is an …

Background Uncertainties persist about the magnitude of associations of diabetes mellitus
and fasting glucose concentration with risk of coronary heart disease and major stroke …

Context Associations of major lipids and apolipoproteins with the risk of vascular disease
have not been reliably quantified. Objective To assess major lipids and apolipoproteins in …

Background: Current guidelines call for high-intensity statin therapy in patients with
cardiovascular disease on the basis of several previous “more versus less statins” trials …

BACKGROUND: Throughout the usual LDL cholesterol range in Western populations, lower
blood concentrations are associated with lower cardiovascular disease risk. In such …

Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in
regulating normal myocardial function and in the adverse myocardial remodeling that occurs …

Objective The frequency of coronary heart disease (CHD) and stroke are increased in
systemic lupus erythematosus (SLE), but the extent of the increase is uncertain. We sought …

Introduction: For half a century, a high level of total cholesterol (TC) or low-density
lipoprotein cholesterol (LDL-C) has been considered to be the major cause of …

Recent studies suggest that statins can function to protect the vasculature in a manner that is
independent of their lipid-lowering activity. We show here that statins rapidly activate the …