The prevalence of cerebrovascular disease increases with age, placing the elderly at a
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …

Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

The blood-brain barrier (BBB) is involved in the pathogenesis of Alzheimer's disease (AD).
BBB is a highly selective semipermeable structural and chemical barrier which ensures a …

The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully
differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the …

While the accumulation and aggregation of amyloid-β and tau are central events in the
pathogenesis of Alzheimer's disease, there is increasing evidence that cerebrovascular …

Efficient processing of information by the central nervous system (CNS) represents an
important evolutionary advantage. Thus, homeostatic mechanisms have developed that …

The existence of a selective blood-brain barrier (BBB) and neurovascular coupling are two
unique central nervous system vasculature features that result in an intimate relationship …

The current pathogenic scenarios of different types of dementia are based on a number of
common mechanisms of neurodegeneration, such as accumulation of abnormal proteins …

Recent reports suggest that functional or structural defect of vascular components are
implicated in amyotrophic lateral sclerosis (ALS) pathology. In the present study, we …

The blood-brain barrier (BBB) comprises the interface between blood, brain and
cerebrospinal fluid. Its primary function, which is mainly carried out by tight junctions, is to …