Natural products play a critical role in the discovery and development of numerous drugs for
the treatment of various types of cancer. These phytochemicals have demonstrated anti …

Molecular dynamics simulations of membranes and membrane proteins serve as
computational microscopes, revealing coordinated events at the membrane interface. As G …

Cancer is, globally, one of the main causes of death. Even though various therapies are
available, they are still painful because of their adverse side effects. Available treatments …

Abstract Background Glioblastoma multiforme (GBM, World Health Organization [WHO]
grade IV) is one of the malignant Central Nerve System (CNS) tumors with high incidence …

The tuberous sclerosis protein complex (TSC complex) is a key integrator of metabolic
signals and cellular stress. In response to nutrient shortage and stresses, the TSC complex …

Here we ask: What is productive signaling? How to define it, how to measure it, and most of
all, what are the parameters that determine it? Further, what determines the strength of …

PIEZO1 is a mechanosensitive channel widely presented in eukaryotic organisms. Although
the PIEZO family was discovered in 2010, main questions related to the molecular structure …

The plasmalemmal norepinephrine transporter (NET) regulates cardiovascular sympathetic
activity by clearing extracellular norepinephrine in the synaptic cleft. Here, we investigate the …

Phospholipase C-βs (PLCβs) catalyze the hydrolysis of phosphatidylinositol 4, 5–
bisphosphate (PIP 2) into inositoltriphosphate (IP3) and diacylglycerol (DAG). PIP 2 …

Background Triple negative breast cancer (TNBC) is a particularly aggressive and difficult-to-
treat subtype of breast cancer that requires the development of novel therapeutic strategies …