The interaction between the sympathetic nervous system and the immune system has been
documented over the last several decades. In this review, the neuroanatomical, cellular, and …

T cell activation depends on extracellular ligation of the T cell receptor (TCR) by peptide–
MHC complexes in a synapse between the T cell and an antigen-presenting cell. The …

INTRODUCTION For T cells to mount an adaptive immune response and enact cell-
mediated immunity, they must first successfully detect rare cognate antigen. This detection is …

We have developed a single-molecule imaging technique that uses quantum-dot-labeled
peptide-major histocompatibility complex (pMHC) ligands to study CD4+ T cell functional …

A T-cell-mediated immune response is initiated by the T-cell receptor (TCR) interacting with
peptide-bound major histocompatibility complex (pMHC) on an infected cell. The …

Membrane interfaces formed at cell–cell junctions are associated with characteristic patterns
of membrane proteins whose organization is critical for intracellular signalling. To isolate the …

Antibodies can block immune receptor engagement or trigger the receptor machinery to
initiate signaling. We hypothesized that antibody agonists trigger signaling by sterically …

T cell activation is initiated by T cell receptor (TCR) phosphorylation. This requires the local
depletion of large receptor-type phosphatases from “close contacts” formed when T cells …

The T cell receptor (TCR) initiates the elimination of pathogens and tumors by T cells. To
avoid damage to the host, the receptor must be capable of discriminating between wild-type …

Natural killer cells assess target cell health via interactions at the immune synapse (IS) that
facilitates signal integration and directed secretion. Here we test whether the IS also …