A variety of targeted anticancer agents have been successfully introduced into clinical
practice, largely reflecting their ability to inhibit specific molecular alterations that are …

DNA repair pathways are triggered to maintain genetic stability and integrity when
mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The …

DNA damage response (DDR) pathway prevents high level endogenous and environmental
DNA damage being replicated and passed on to the next generation of cells via an …

In order to maintain genomic stability, cells have developed sophisticated signalling
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …

During the last few decades, improvements in the planning and application of radiotherapy
in combination with surgery and chemotherapy resulted in increased survival rates of tumor …

Alterations in DNA damage response (DDR) pathways are hallmarks of cancer. Incorrect
repair of DNA lesions often leads to genomic instability. Ataxia telangiectasia mutated …

The repair of DNA damage is a complex process that relies on particular pathways to
remedy specific types of damage to DNA. The range of insults to DNA includes small …

Cellular responses to DNA damage are important determinants of both cancer development
and cancer outcome following radiation therapy and chemotherapy. Identification of …

Poor survival rates of patients with tumors arising from or disseminating into the brain are
attributed to an inability to excise all tumor tissue (if operable), a lack of blood-brain barrier …

DNA double-strand breaks are the critical lesions responsible for the majority of ionizing
radiation–induced cell killing. Thus, the ability of tumor cells to elicit a DNA damage …