Neurodegenerative diseases are characterised by progressive damage to the nervous
system including the selective loss of vulnerable populations of neurons leading to motor …

α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

Cancer is a global issue majorly affecting developing countries. According to a survey, 63%
of deaths due to cancer are reported from developing countries. There are different …

Mammalian cells remove misfolded proteins using various proteolytic systems, including the
ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and …

Most of the mammalian genome is transcribed,,. This generates a vast repertoire of
transcripts that includes protein-coding messenger RNAs, long non-coding RNAs (lncRNAs) …

Parkinson's disease (PD) is characterized by the selective loss of dopaminergic neurons of
the substantia nigra pars compacta (SNc) with motor and nonmotor symptoms. Defective …

The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways,
where abnormal UPS function has been observed in cancer and neurological diseases …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

An enormous amount of long non-coding RNAs (lncRNAs) transcribed from eukaryotic
genome are important regulators in different aspects of cellular events. Cytoplasm is the …

Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the
substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic …