As an ancient infectious disease, tuberculosis (TB) is still the leading cause of death from a
single infectious agent worldwide. Latent TB infection (LTBI) has been recognized as the …

Chiral amino acids are extensively applied in the pharmaceutical, food, cosmetic,
agricultural, and feedstuff industries. The development of synthetic methodologies for …

Abstract NAD (P) H-dependent oxidoreductases catalyze the reduction or oxidation of a
substrate coupled to the oxidation or reduction, respectively, of a nicotinamide adenine …

Energy metabolism is a universal process occurring in all life forms. In Mycobacterium
tuberculosis (Mtb), energy production is carried out in two possible ways, oxidative …

Abstract Alanine dehydrogenase (AlaDH)(EC 1.4. 1.1) is a microbial enzyme that catalyzes
a reversible conversion of L-alanine to pyruvate. Inter-conversion of alanine and pyruvate by …

Background Although currently available IGRA have been reported to be promising markers
for TB infection, they cannot distinguish active tuberculosis (TB) from latent infection (LTBI) …

Objectives High accuracy diagnostic screening tests for tuberculosis (TB) are required to
improve the diagnosis of both active TB and latent Mycobacterium tuberculosis (MTB) …

Abstract Background Alanine dehydrogenase (AlaDH) belongs to oxidoreductases, and it
exists in several different bacteria species and plays a key role in microbial carbon and …

The putative glycine dehydrogenase of Mycobacterium tuberculosis catalyzes the reductive
amination of glyoxylate to glycine but not the reverse reaction. The enzyme was purified and …

The quaternary structure with specific stoichiometry is pivotal to the specific function of
protein complexes. However, determining the structure of many protein complexes …