Ubiquitin-binding domains (UBDs) are modular elements that bind non-covalently to the
protein modifier ubiquitin. Recent atomic-level resolution structures of ubiquitin–UBD …

Histone deacetylases (HDACs) are a diverse family of essential transcriptional regulatory
enzymes, that function through the spatial and temporal recruitment of protein complexes. As …

Post-translational modification by ubiquitin (ubiquitination, ubiquitylation, ubiquitinylation) is
used as a robust signaling mechanism in a variety of processes that are essential for cell …

Abstract The AAA+ ATPase p97/VCP together with different sets of substrate-delivery
adapters and accessory cofactor proteins unfolds ubiquitinated substrates to facilitate …

WD40-repeat β-propellers are found in a wide range of proteins involved in distinct
biological activities. We define a large subset of WD40 β-propellers as a class of ubiquitin …

Mitochondria-associated degradation (MAD) mediated by the Cdc48 complex and
proteasome degrades ubiquitinated mitochondrial outer-membrane proteins. MAD is critical …

Ubiquitination controls a plethora of cellular processes. Modifications by linear polyubiquitin
have so far been linked with acquired and innate immunity, lymphocyte development and …

Chromatin is the context for all DNA-based molecular processes taking place in the cell
nucleus. The initial chromatin structure at the site of the DNA damage determines both …

Mammalian BAF complexes are a subfamily of SWI/SNF ATP-dependent chromatin
remodelers that dynamically modulate chromatin structure to regulate fundamental cellular …

Ubiquitin modifications of target proteins act to localise, direct and specify a diverse range of
cellular processes, many of which are biomedically relevant. To allow this diversity, ubiquitin …