Quadruplex-forming sequences are widely prevalent in human and other genomes,
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …

The intriguing structural diversity in folded topologies available to guanine-rich nucleic acid
repeat sequences have made four-stranded G-quadruplex structures the focus of both basic …

The identification of the molecular events that drive cancer transformation is essential to the
development of targeted agents that improve the clinical outcome of lung cancer. Many …

Enzymes of the TET family are methylcytosine dioxygenases that undergo frequent
mutational or functional inactivation in human cancers. Recurrent loss-of-function mutations …

G‐quadruplexes are four‐stranded nucleic acid structures whose biological functions
remain poorly understood. In the yeast S. cerevisia e, we report that G‐quadruplexes form …

Four-stranded G-quadruplex DNA secondary structures have recently been visualized in the
nuclei of human cultured cells. Here, we show that BG4, a G-quadruplex-specific antibody …

Nonhomologous DNA end joining (NHEJ) is one of the major double-strand break (DSB)
repair pathways in higher eukaryotes. Recently, it has been shown that alternative NHEJ (A …

G4 DNA is a non-canonical DNA structure consisting of a stacked array of Gquartets held
together by base pairing between guanine bases. The formation of G4 DNA requires a …

Gross chromosomal rearrangements (including translocations, deletions, insertions and
duplications) are a hallmark of cancer genomes and often create oncogenic fusion genes …

Our genome contains many G‐rich sequences, which have the propensity to fold into stable
secondary DNA structures called G4 or G‐quadruplex structures. These structures have …