Following the discovery of inositol-1, 4, 5-trisphosphate as a second messenger, many other
inositol phosphates were discovered in quick succession, with some understanding of their …

The present review will explore the insights gained into inositol pyrophosphates in the 20
years since their discovery in 1993. These molecules are defined by the presence of the …

Nutrient availability regulates life-span in a wide range of organisms. We demonstrate that in
mammalian cells, acute nutrient withdrawal simultaneously augments expression of the …

Abstract Phytic acid (myo-inositol-1, 2, 3, 4, 5, 6-hexa kis phosphate or Ins P6) typically
represents approximately 75% to 80% of maize (Zea mays) seed total P. Here we describe …

In plants, phosphate (P i) homeostasis is regulated by the interaction of PHR transcription
factors with stand-alone SPX proteins, which act as sensors for inositol pyrophosphates. In …

Inositol phospholipids and inositol phosphates mediate well‐established functions in signal
transduction and in Ca2+ homeostasis in the CNS and non‐neural tissues. More recently …

Abstract Inositol (1, 4, 5) trisphosphate (Ins (1, 4, 5) P 3) is a well-known messenger
molecule that releases calcium from intracellular stores. Homologues with up to six …

Phosphate, as a cellular energy currency, essentially drives most biochemical reactions
defining living organisms, and thus its homeostasis must be tightly regulated. Investigation …

The inositol pyrophosphates IP7 and IP8 contain highly energetic pyrophosphate bonds.
Although implicated in various biologic functions, their molecular sites of action have not …

Phosphate's central role in most biochemical reactions in a living organism requires
carefully maintained homeostasis. Although phosphate homeostasis in mammals has long …