Highlights•Chromatin folding into topologically associated domains (TADs) is pervasive
across animal groups.•TADs are plastic entities composed of genomic strata from different …

Genomes have complex three-dimensional structures. High-resolution population-based
biochemical studies over the last decade have painted a mostly static picture of the genome …

Although promoters and their enhancers are frequently contained within a topologically
associating domain (TAD), some developmentally important genes have their promoter and …

Fingerprints are of long-standing practical and cultural interest, but little is known about the
mechanisms that underlie their variation. Using genome-wide scans in Han Chinese …

The specificity of gene expression during development requires the insulation of regulatory
domains to avoid inappropriate enhancer-gene interactions. In vertebrates, this insulator …

Capture Hi-C is widely used to obtain high-resolution profiles of chromosomal interactions
involving, at least on one end, regions of interest such as gene promoters. Signal detection …

The specificity of gene expression during development requires the insulation of regulatory
domains to avoid inappropriate enhancer-gene interactions. In vertebrates, this insulator …

Abstract Information on how 3D genome topology emerged in animal evolution, how stable it
is during development, its role in the evolution of phenotypic novelties and how exactly it …

Enhancers are remotely located noncoding DNA sequences that regulate gene expression
in response to developmental, homeostatic, and environmental cues. Canonical short-range …

The expression of some genes depends on large, adjacent regions of the genome that
contain multiple enhancers. These regulatory landscapes frequently align with Topologically …