Background Wearable devices hold great promise, particularly for data generation for cutting-
edge health research, and their demand has risen substantially in recent years. However …

Background Escalating awareness of the magnitude of the challenge posed by low levels of
physical activity in people with chronic obstructive pulmonary disease (COPD) highlights the …

Introduction Pragmatic randomized controlled trials (RCTs) mimic usual clinical practice and
they are critical to inform decision-making by patients, clinicians and policy-makers in real …

Importance Chronic breathlessness is common in people with chronic obstructive pulmonary
disease (COPD). Regular, low-dose, extended-release morphine may relieve …

Breathlessness, dyspnoea and shortness of breath are synonymous terms to describe the
'subjective experience of breathing discomfort that consists of qualitatively distinct …

Introduction Morphine may decrease the intensity of chronic breathlessness but data from a
large randomised controlled trial (RCT) are lacking. This first, large, parallel-group trial …

Chronic breathlessness is a disabling and distressing condition for which there is a growing
evidence base for a range of interventions. Non-pharmacological interventions are the …

Background Chronic breathlessness is a recognized clinical syndrome that severely impacts
patients and carers, who become increasingly restricted in their daily activities. Often …

Background Providing palliative care to patients with chronic obstructive pulmonary disease
(COPD) is a priority. Spirometry demonstrating airflow limitation is a diagnostic test for COPD …

Abstract Background and Objective Preference-based outcome measures are commonly
applied in economic analyses to inform healthcare resource allocation decisions. Few …