Age-related macular degeneration

EK de Jong, MJ Geerlings, AI den Hollander - Genetics and genomics of …, 2020 - Elsevier
Age-related macular degeneration (AMD) is a multifactorial disease influenced by a
combination of environmental factors and genetic variants. Genomic studies have been …

[HTML][HTML] The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment

MJ Geerlings, EK de Jong, AI den Hollander - Molecular immunology, 2017 - Elsevier
Age-related macular degeneration (AMD) is a progressive retinal disease and the major
cause of irreversible vision loss in the elderly. Numerous studies have found both common …

Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration

V Cipriani, L Lorés-Motta, F He, D Fathalla… - Nature …, 2020 - nature.com
Age-related macular degeneration (AMD) is a leading cause of blindness. Genetic variants
at the chromosome 1q31. 3 encompassing the complement factor H (CFH, FH) and CFH …

The Role of Inflammation in Age-Related Macular Degeneration—Therapeutic Landscapes in Geographic Atrophy

GA Borchert, H Shamsnajafabadi, ML Hu, SR De Silva… - Cells, 2023 - mdpi.com
Age-related macular degeneration (AMD) is the leading cause of vision loss and visual
impairment in people over 50 years of age. In the current therapeutic landscape, intravitreal …

[HTML][HTML] Implications of genetic variation in the complement system in age-related macular degeneration

S de Jong, G Gagliardi, A Garanto, A de Breuk… - Progress in Retinal and …, 2021 - Elsevier
Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly
in the Western world. While AMD is a multifactorial disease, the complement system was …

Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular …

L Lorés-Motta, AE van Beek, E Willems… - The American Journal of …, 2021 - cell.com
Age-related macular degeneration (AMD) is the principal cause of blindness in the elderly
population. A strong effect on AMD risk has been reported for genetic variants at the CFH …

[HTML][HTML] Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration

E Kersten, CC Paun, RL Schellevis, CB Hoyng… - survey of …, 2018 - Elsevier
Biomarkers can help unravel mechanisms of disease and identify new targets for therapy.
They can also be useful in clinical practice for monitoring disease progression, evaluation of …

Age‐related macular degeneration: A disease of extracellular complement amplification

S de Jong, J Tang, SJ Clark - Immunological reviews, 2023 - Wiley Online Library
Age‐related macular degeneration (AMD) is a major cause of vision impairment in the
Western World, and with the aging world population, its incidence is increasing. As of today …

Complement Inhibitors in Age‐Related Macular Degeneration: A Potential Therapeutic Option

S Qin, N Dong, M Yang, J Wang… - Journal of …, 2021 - Wiley Online Library
Age‐related macular degeneration (AMD) is a multifactorial disease, which can culminate in
irreversible vision loss and blindness in elderly. Nowadays, there is a big gap between dry …

[HTML][HTML] Development of a genotype assay for age-related macular degeneration: the EYE-RISK Consortium

A de Breuk, IE Acar, E Kersten, MM Schijvenaars… - Ophthalmology, 2021 - Elsevier
Purpose To develop a genotype assay to assess associations with common and rare age-
related macular degeneration (AMD) risk variants, to calculate an overall genetic risk score …