Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …

The tyrosinase enzyme, which is widely found in microorganisms, animals and plants, has a
significant position in melanogenesis, plays an important role in undesirable browning of …

Tyrosinases are responsible for melanin formation in all life domains. Tyrosinase inhibitors
are used for the prevention of severe skin diseases, in skin-whitening creams and to avoid …

Tyrosinase (TYR, EC 1.14. 18.1), a critical enzyme participating in melanogenesis, catalyzes
the first two steps in melanin biosynthesis including the ortho-hydroxylation of L-tyrosine and …

The phenomenon of today's ageing population has increased interest in the search for new
active substances that delay the onset and development of neurodegenerative diseases. In …

Tyrosinase plays an essential role in melanogenesis. Excess production of melanin can be
a reason for hyperpigmentation skin disorders in mammals and enzymatic browning in plant …

Studies on the discovery of tyrosinase enzyme inhibitors and exploration for better cytotoxic
agents remain an important line in drug discovery and development. A series of synthetic …

Melanoma is an aggressive form of skin cancer, being one of the deadliest cancers in the
world. The current treatment options involve surgery, radiotherapy, targeted therapy …

Among the human copper-containing monooxygenases, Tyrosinase (Ty) is an important
enzyme involved in the determinant step of the biosynthetic pathway of melanin pigment. In …

With the aim to develop effective and selective human tyrosinase inhibitors, we investigated
aurone derivatives whose B-ring was replaced by a non-oxidizable 2-hydroxypyridine-N …