PET/MRI: where might it replace PET/CT?
EC Ehman, GB Johnson… - Journal of Magnetic …, 2017 - Wiley Online Library
Simultaneous positron emission tomography and MRI (PET/MRI) is a technology that
combines the anatomic and quantitative strengths of MR imaging with physiologic …
combines the anatomic and quantitative strengths of MR imaging with physiologic …
Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation
SY Cheon, J Song - Cell & Bioscience, 2022 - Springer
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by multiple
pathologies. The progression of dementia with NAFLD may be affected by various risk …
pathologies. The progression of dementia with NAFLD may be affected by various risk …
Ultra–Low-Dose 18F-Florbetaben Amyloid PET Imaging Using Deep Learning with Multi-Contrast MRI Inputs
Purpose To reduce radiotracer requirements for amyloid PET/MRI without sacrificing
diagnostic quality by using deep learning methods. Materials and Methods Forty data sets …
diagnostic quality by using deep learning methods. Materials and Methods Forty data sets …
Ultra‐low‐dose PET reconstruction using generative adversarial network with feature matching and task‐specific perceptual loss
Purpose Our goal was to use a generative adversarial network (GAN) with feature matching
and task‐specific perceptual loss to synthesize standard‐dose amyloid Positron emission …
and task‐specific perceptual loss to synthesize standard‐dose amyloid Positron emission …
Noninvasive molecular imaging of neuroinflammation
AH Jacobs, B Tavitian… - Journal of Cerebral …, 2012 - journals.sagepub.com
Inflammation is a highly dynamic and complex adaptive process to preserve and restore
tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous …
tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous …
Potential new approaches for diagnosis of Alzheimer's disease and related dementias
Dementia is an umbrella term—caused by a large number of specific diagnoses, including
several neurodegenerative disorders. Alzheimer's disease (AD) is now the most common …
several neurodegenerative disorders. Alzheimer's disease (AD) is now the most common …
The potential role of cytokines and growth factors in the pathogenesis of Alzheimer's disease
G Ogunmokun, S Dewanjee, P Chakraborty… - Cells, 2021 - mdpi.com
Alzheimer's disease (AD) is one of the most prominent neurodegenerative diseases, which
impairs cognitive function in afflicted individuals. AD results in gradual decay of neuronal …
impairs cognitive function in afflicted individuals. AD results in gradual decay of neuronal …
Significance of brain glucose hypometabolism, altered insulin signal transduction, and insulin resistance in several neurological diseases
E Blázquez, V Hurtado-Carneiro… - Frontiers in …, 2022 - frontiersin.org
Several neurological diseases share pathological alterations, even though they differ in their
etiology. Neuroinflammation, altered brain glucose metabolism, oxidative stress …
etiology. Neuroinflammation, altered brain glucose metabolism, oxidative stress …
Microglial malfunction: the third rail in the development of Alzheimer's disease
Studies of Alzheimer's disease (AD) have predominantly focused on two major pathologies:
amyloid-β (Aβ) and hyperphosphorylated tau. These misfolded proteins can accumulate …
amyloid-β (Aβ) and hyperphosphorylated tau. These misfolded proteins can accumulate …
Imaging of neuroinflammation in dementia: a review
J Stefaniak, J O'Brien - Journal of Neurology, Neurosurgery & …, 2016 - jnnp.bmj.com
We are still very limited in management strategies for dementia, and establishing effective
disease modifying therapies based on amyloid or tau remains elusive. Neuroinflammation …
disease modifying therapies based on amyloid or tau remains elusive. Neuroinflammation …