PET/MRI: where might it replace PET/CT?

EC Ehman, GB Johnson… - Journal of Magnetic …, 2017 - Wiley Online Library
Simultaneous positron emission tomography and MRI (PET/MRI) is a technology that
combines the anatomic and quantitative strengths of MR imaging with physiologic …

Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation

SY Cheon, J Song - Cell & Bioscience, 2022 - Springer
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by multiple
pathologies. The progression of dementia with NAFLD may be affected by various risk …

Ultra–Low-Dose 18F-Florbetaben Amyloid PET Imaging Using Deep Learning with Multi-Contrast MRI Inputs

KT Chen, E Gong, FB de Carvalho Macruz, J Xu… - Radiology, 2019 - pubs.rsna.org
Purpose To reduce radiotracer requirements for amyloid PET/MRI without sacrificing
diagnostic quality by using deep learning methods. Materials and Methods Forty data sets …

Ultra‐low‐dose PET reconstruction using generative adversarial network with feature matching and task‐specific perceptual loss

J Ouyang, KT Chen, E Gong, J Pauly… - Medical …, 2019 - Wiley Online Library
Purpose Our goal was to use a generative adversarial network (GAN) with feature matching
and task‐specific perceptual loss to synthesize standard‐dose amyloid Positron emission …

Noninvasive molecular imaging of neuroinflammation

AH Jacobs, B Tavitian… - Journal of Cerebral …, 2012 - journals.sagepub.com
Inflammation is a highly dynamic and complex adaptive process to preserve and restore
tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous …

Potential new approaches for diagnosis of Alzheimer's disease and related dementias

RS Turner, T Stubbs, DA Davies, BC Albensi - Frontiers in neurology, 2020 - frontiersin.org
Dementia is an umbrella term—caused by a large number of specific diagnoses, including
several neurodegenerative disorders. Alzheimer's disease (AD) is now the most common …

The potential role of cytokines and growth factors in the pathogenesis of Alzheimer's disease

G Ogunmokun, S Dewanjee, P Chakraborty… - Cells, 2021 - mdpi.com
Alzheimer's disease (AD) is one of the most prominent neurodegenerative diseases, which
impairs cognitive function in afflicted individuals. AD results in gradual decay of neuronal …

Significance of brain glucose hypometabolism, altered insulin signal transduction, and insulin resistance in several neurological diseases

E Blázquez, V Hurtado-Carneiro… - Frontiers in …, 2022 - frontiersin.org
Several neurological diseases share pathological alterations, even though they differ in their
etiology. Neuroinflammation, altered brain glucose metabolism, oxidative stress …

Microglial malfunction: the third rail in the development of Alzheimer's disease

SD Mhatre, CA Tsai, AJ Rubin, ML James… - Trends in …, 2015 - cell.com
Studies of Alzheimer's disease (AD) have predominantly focused on two major pathologies:
amyloid-β (Aβ) and hyperphosphorylated tau. These misfolded proteins can accumulate …

Imaging of neuroinflammation in dementia: a review

J Stefaniak, J O'Brien - Journal of Neurology, Neurosurgery & …, 2016 - jnnp.bmj.com
We are still very limited in management strategies for dementia, and establishing effective
disease modifying therapies based on amyloid or tau remains elusive. Neuroinflammation …