Advances in applying computer-aided drug design for neurodegenerative diseases
Neurodegenerative diseases (NDs) including Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and Huntington's disease are incurable and affect millions of …
amyotrophic lateral sclerosis, and Huntington's disease are incurable and affect millions of …
Natural and synthetic naphthoquinones as potential anti-infective agents
Background: Naphthoquinones are a class of aromatic compounds relevant for their
chemical characteristics, structural properties, and biological activity. These compounds are …
chemical characteristics, structural properties, and biological activity. These compounds are …
Design, synthesis and investigation of the mechanism of action underlying anti-leukemic effects of the quinolinequinones as LY83583 analogs
Literature conclusively shows that one of the quinolinequinone analogs (6-anilino-5, 8-
quinolinequinone), referred to as LY83583 hereafter, an inhibitor of guanylyl cyclase, was …
quinolinequinone), referred to as LY83583 hereafter, an inhibitor of guanylyl cyclase, was …
Structure based design, synthesis, and evaluation of anti-CML activity of the quinolinequinones as LY83583 analogs
Quinone-based small molecules are the promising structures for antiproliferative drug
design and can induce apoptosis in cancer cells. Among them, one of the …
design and can induce apoptosis in cancer cells. Among them, one of the …
On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity
GAM Jardim, WJ Reis, MF Ribeiro, FM Ottoni… - RSC …, 2015 - pubs.rsc.org
In our continued search for novel trypanocidal compounds, arylamine, chalcone, triazolic,
triazole–carbohydrate and chalcogenium derivatives containing a naphthoquinone scaffold …
triazole–carbohydrate and chalcogenium derivatives containing a naphthoquinone scaffold …
Mode of action of p-quinone derivatives with trypanocidal activity studied by experimental and in silico models
A Ballesteros-Casallas, C Quiroga, C Ortiz… - European Journal of …, 2023 - Elsevier
Quinones are attractive pharmacological scaffolds for developing new agents for the
treatment of different transmissible and non-transmissible human diseases due to their …
treatment of different transmissible and non-transmissible human diseases due to their …
New Amino Naphthoquinone Derivatives as Anti-Trypanosoma cruzi Agents Targeting Trypanothione Reductase
C Espinosa-Bustos, M Ortiz Pérez… - Pharmaceutics, 2022 - mdpi.com
To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this
study, a set of new amino naphthoquinone derivatives were synthesised and evaluated in …
study, a set of new amino naphthoquinone derivatives were synthesised and evaluated in …
Trypanothione reductase: a target for the development of anti-Trypanosoma cruzi drugs
Background & Objective: Chagas disease or American trypanosomiasis is a major parasitic
disease in Latin America with restricted available treatment: nifurtimox and benznidazole …
disease in Latin America with restricted available treatment: nifurtimox and benznidazole …
New benzimidazolequinones as trypanosomicidal agents
Herein, the design and synthesis of new 2-phenyl (pyridinyl) benzimidazolequinones and
their 5-phenoxy derivatives as potential anti-Trypanosoma cruzi agents are described. The …
their 5-phenoxy derivatives as potential anti-Trypanosoma cruzi agents are described. The …
Targets and patented drugs for chemotherapy of Chagas disease in the last 15 years-period
VG Duschak - Recent patents on anti-infective drug discovery, 2016 - ingentaconnect.com
Background: The American trypanosomiasis, Chagas disease, is a parasitic infection
typically spread by triatomine vectors affecting millions of people all over Latin America …
typically spread by triatomine vectors affecting millions of people all over Latin America …