Gut microbial molecules in behavioural and neurodegenerative conditions

BD Needham, R Kaddurah-Daouk… - Nature Reviews …, 2020 - nature.com
Mounting evidence suggests that the gut microbiome impacts brain development and
function. Gut–brain connections may be mediated by an assortment of microbial molecules …

Bioactive lipids and chronic inflammation: managing the fire within

V Chiurchiù, A Leuti, M Maccarrone - Frontiers in immunology, 2018 - frontiersin.org
Inflammation is an immune response that works as a contained fire that is pre-emptively
sparked as a defensive process during infections or upon any kind of tissue insult, and that …

Bioactive lipids, inflammation and chronic diseases

A Leuti, D Fazio, M Fava, A Piccoli, S Oddi… - Advanced Drug Delivery …, 2020 - Elsevier
Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses

V Chiurchiù, A Leuti, J Dalli, A Jacobsson… - Science translational …, 2016 - science.org
Resolution of inflammation is a finely regulated process mediated by specialized
proresolving lipid mediators (SPMs), including docosahexaenoic acid (DHA)–derived …

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

CN Serhan, N Chiang, J Dalli - Molecular aspects of medicine, 2018 - Elsevier
While protective, the acute inflammatory response when uncontrolled can lead to further
tissue damage and chronic inflammation that is now widely recognized to play important …

Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis

T Ishihara, M Yoshida, M Arita - International immunology, 2019 - academic.oup.com
Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid,
docosapentaenoic acid and docosahexaenoic acid, display a wide range of beneficial …

Electrical stimulation of the vagus nerve ameliorates inflammation and disease activity in a rat EAE model of multiple sclerosis

C Natarajan, LHD Le, M Gunasekaran… - Proceedings of the …, 2024 - pnas.org
Multiple sclerosis (MS) is a demyelinating central nervous system (CNS) disorder that is
associated with functional impairment and accruing disability. There are multiple US Food …

Unsaturated fatty acids and their immunomodulatory properties

S Coniglio, M Shumskaya, E Vassiliou - Biology, 2023 - mdpi.com
Simple Summary Diet can influence human health in both positive and negative ways. Ω-3
polyunsaturated fatty acids have an overall positive effect on humans. The sources of these …

Resolution of inflammation during multiple sclerosis

F Ruiz, S Vigne, C Pot - Seminars in immunopathology, 2019 - Springer
Multiple sclerosis (MS) is a frequent autoimmune demyelinating disease of the central
nervous system (CNS). There are three clinical forms described: relapsing-remitting multiple …

Potential clinical applications of pro-resolving lipids mediators from docosahexaenoic acid

MP Beyer, LA Videla, C Farías, R Valenzuela - Nutrients, 2023 - mdpi.com
Docosahexaenoic acid (C22: 6 n-3, DHA) is the precursor of specialized pro-resolving lipid
mediators (SPMs), such as resolvin, protectin, and maresin families which have been …