[HTML][HTML] The role of alternative splicing in cancer: From oncogenesis to drug resistance
R Sciarrillo, A Wojtuszkiewicz, YG Assaraf… - Drug Resistance …, 2020 - Elsevier
Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …
mRNA are removed and protein-coding segments are assembled in diverse combinations …
[HTML][HTML] Comprehensive analysis of alternative splicing across tumors from 8,705 patients
Our comprehensive analysis of alternative splicing across 32 The Cancer Genome Atlas
cancer types from 8,705 patients detects alternative splicing events and tumor variants by …
cancer types from 8,705 patients detects alternative splicing events and tumor variants by …
Neuroendocrine-immune interaction: Evolutionarily conserved mechanisms that maintain allostasis in an ever-changing environment
BML Verburg-van Kemenade, N Cohen… - Developmental & …, 2017 - Elsevier
It has now become accepted that the immune system and neuroendocrine system form an
integrated part of our physiology. Immunological defense mechanisms act in concert with …
integrated part of our physiology. Immunological defense mechanisms act in concert with …
[HTML][HTML] Mechanism of alternative splicing and its regulation
Y Wang, J Liu, BO Huang, YM Xu, J Li… - Biomedical …, 2015 - spandidos-publications.com
Alternative splicing of precursor mRNA is an essential mechanism to increase the
complexity of gene expression, and it plays an important role in cellular differentiation and …
complexity of gene expression, and it plays an important role in cellular differentiation and …
[HTML][HTML] Differential fates of introns in gene expression due to global alternative splicing
The discovery of introns over four decades ago revealed a new vision of genes and their
interrupted arrangement. Throughout the years, it has appeared that introns play essential …
interrupted arrangement. Throughout the years, it has appeared that introns play essential …
[HTML][HTML] Alternative splicing as a biomarker and potential target for drug discovery
K Le, BS Prabhakar, W Hong, L Li - Acta Pharmacologica Sinica, 2015 - nature.com
Alternative splicing is a key process of multi-exonic gene expression during pre-mRNA
maturation. In this process, particular exons of a gene will be included within or excluded …
maturation. In this process, particular exons of a gene will be included within or excluded …
RBFOX2 alters splicing outcome in distinct binding modes with multiple protein partners
RBFOX2 controls the splicing of a large number of transcripts implicated in cell
differentiation and development. Parsing RNA-binding protein datasets, we uncover that …
differentiation and development. Parsing RNA-binding protein datasets, we uncover that …
Toward in silico identification of tumor neoantigens in immunotherapy
C Zhou, C Zhu, Q Liu - Trends in molecular medicine, 2019 - cell.com
Cancer immunotherapy includes cancer vaccination, adoptive T cell transfer (ACT) with
chimeric antigen receptor (CAR) T cells, and administration of tumor-infiltrating lymphocytes …
chimeric antigen receptor (CAR) T cells, and administration of tumor-infiltrating lymphocytes …
The UGTome: The expanding diversity of UDP glycosyltransferases and its impact on small molecule metabolism
The UDP glycosyltransferase (UGT) superfamily of enzymes is responsible for the
metabolism and clearance of thousands of lipophilic chemicals including drugs, toxins and …
metabolism and clearance of thousands of lipophilic chemicals including drugs, toxins and …
[HTML][HTML] Discerning novel splice junctions derived from RNA-seq alignment: a deep learning approach
Y Zhang, X Liu, J MacLeod, J Liu - BMC genomics, 2018 - Springer
Background Exon splicing is a regulated cellular process in the transcription of protein-
coding genes. Technological advancements and cost reductions in RNA sequencing have …
coding genes. Technological advancements and cost reductions in RNA sequencing have …