A recurrent theme in embryonic development and tissue regeneration is that cells
communicate with each other using just a handful of conserved families of signaling …

Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins,
nesprins and SUN-domain proteins. These complexes have roles in chromatin organization …

Bone morphogenetic protein-4 (BMP-4) is a member of the TGF-beta superfamily of
polypeptide signaling molecules, closely related to BMP-2 and to Drosophila …

Signals released by the Spemann organizer of the amphibian gastrula can directly induce
neural tissue from ectoderm and can dorsalize ventral mesoderm to form muscle. The …

The TGF-β superfamily of proteins regulates many different biological processes, including
cell growth, differentiation and embryonic pattern formation,,. TGF-β-like factors signal …

Chordin (Chd) is an abundant protein secreted by Spemann organizer tissue during
gastrulation. Chd antagonizes signaling by mature bone morphogenetic proteins (BMPs) by …

The cellular interactions that control the differentiation of dorsal cell types from neural
progenitors have been examined in neural plate explants. Certain genes that are expressed …

Bone morphogenetic proteins (BMPs) are secreted proteins that interact with cell-surface
receptors and are believed to play a variety of important roles during vertebrate …

In the chick, heart mesoderm is induced by signals from the anterior endoderm. Although
BMP-2 is expressed in the anterior endoderm, BMP activity is necessary but not sufficient for …

▪ Abstract We review the current status of research in dorsal-ventral (DV) patterning in
vertebrates. Emphasis is placed on recent work on Xenopus, which provides a paradigm for …