PTP1B is a classical non-transmembrane protein tyrosine phosphatase that plays a key role
in metabolic signaling and is a promising drug target for type 2 diabetes and obesity …

Glucose is the major energy supply and a critical metabolite for most cells and is especially
important when cell is differentiating. High or low concentrations of glucose enhances or …

In this study, we aimed to identify the mechanisms underlying the different effects of palmitic
acid and oleic acid on human pancreatic beta cell function. To address this problem, the …

To test the hypothesis that aging impairs endothelial cell response to glucose stress, we
utilized a human umbilical vein endothelial cell in vitro model in which clinically relevant …

There is constant increase in number of diabetic cases thereby giving it status of a serious
epidemic. Diabetes increases the risk of occurrence of several cancers including breast …

An increasing number of patients diagnosed with diabetes mellitus eventually develop
severe coronary atherosclerosis disease. Both type 1 and type 2 diabetes mellitus increase …

Adipocytes exposed to high glucose concentrations exhibit impaired metabolic function,
including an increase of oxidative and proinflammatory factors that might favor the …

Abnormal migration and proliferation of vascular smooth muscle cells (VSMCs) are the
pathological basis of hyperplasia during vein graft disease. It remains unknown if circular …

Proliferation of vascular smooth muscle cells (VSMCs) plays an important role in the
development and progression of diabetes-related vascular complications.(−) …

The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of
atherosclerosis induced by high glucose. Mevalonate pathway is an important metabolic …