Cytokines are among the most important effector and messenger molecules in the immune
system. They profoundly participate in immune responses during infection and inflammation …

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …

Abstract Interleukin-22 (IL-22) is a key effector molecule that is produced by activated T cells,
including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate …

Chronic mucosal inflammation and tissue damage predisposes patients to the development
of colorectal cancer. This association could be explained by the hypothesis that the same …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

Chronic inflammation is linked to the development of multiple cancers, including those of the
colon. Inflammation in the gut induces carcinogenic mutagenesis and promotes colorectal …

The maintenance of barrier function at exposed surfaces of the mammalian body is essential
for limiting exposure to environmental stimuli, preventing systemic dissemination of …

CD4+ T cells, upon activation and expansion, develop into different T helper cell subsets
with different cytokine profiles and distinct effector functions. Until recently, T cells were …

T helper 17 (Th17) cells belong to a recently identified T helper subset, in addition to the
traditional Th1 and Th2 subsets. These cells are characterized as preferential producers of …

IL-22 is a relatively new cytokine that is characterized by several unique biological
properties. In the intestines, the effect of IL-22 is restricted mainly to non-lymphoid cells such …