IKAROS is a master regulator of cell fate determination in lymphoid and other hematopoietic
cells. This transcription factor orchestrates the association of epigenetic regulators with …

The IKZF 1 gene at 7p12. 2 codes for IKAROS (also termed IKZF 1), an essential
transcription factor in haematopoiesis involved primarily in lymphoid differentiation. Its …

RNA alternative splicing, a post-transcriptional stage in eukaryotes, is crucial in cellular
homeostasis and disease processes. Due to the rapid development of the next-generation …

C2H2 zinc fingers are found in several key transcriptional regulators in the immune system.
However, these proteins usually contain more fingers than are needed for sequence-specific …

IL-7 is critical for B cell production in adult mice; however, its role in human B lymphopoiesis
is controversial. One challenge was the inability to differentiate human cord blood (CB) or …

Natural killer (NK) cells play an important role in host defense against tumors and viruses
and other infectious diseases. NK cell development is regulated by mechanisms that are …

Pancreatic cancer (PC) evades immune destruction by favoring the development of
regulatory T cells (Tregs) that inhibit effector T cells. The transcription factor Ikaros is critical …

Ikzf1 is a Krüppel-like zinc-finger transcription factor that plays indispensable roles in T and
B cell development. Although the function of Ikzf1 has been studied extensively, the …

DNA-binding protein Ikaros is a major determinant of haematopoietic lineage, especially in
the development, differentiation and proliferation of lymphocytes. In the present study, a …

Alternative splicing expands the transcriptome thereby promoting protein diversity. It governs
critical cellular processes such as differentiation, proliferation and apoptosis in a tissue …