Phosphorylation is an essential process in biological events and is considered critical for
biological functions. In tissues, protein phosphorylation mainly occurs on tyrosine (Tyr) …

Abstract Thiazolidinediones (TZDs) or Glitazones are an important class of insulin
sensitizers used in the treatment of Type 2 diabetes mellitus (T2DM). TZDs were reported for …

Abstract Hydantoin, imidazolidine-2, 4-dione, is a non-aromatic five-membered heterocycle,
which is considered a valuable, privileged scaffold in medicinal chemistry. The importance …

Insulin resistance, the most important characteristic of the type 2 diabetes mellitus (T2DM), is
mostly caused by impairment in the insulin receptor (IR) signal transduction pathway …

The aim of this review was to discuss an overview of type 2 diabetes; biology of PTP1B; role
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …

Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …

Background: Diabetes Mellitus (DM), is a metabolic disorder characterized by high blood
glucose levels. The main types of diabetes mellitus are Diabetes mellitus type I, Diabetes …

Thiazolidinones and phenylaminopyrimidines are known as anticancer agents. Imatinib is
the pioneer phenylaminopyrimidine derivative kinase inhibitor, which is used for the …

Diabetes mellitus is a systemic disease responsible for morbidity in the western world and is
gradually becoming prevalent in developing countries too. The prevalence of diabetes is …

Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such,
tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential …