Lysosomes are degradation centers and signaling hubs in cells and play important roles in
cellular homeostasis, development, and aging. Changes in lysosome function are essential …

Phagocytosis is a fundamental process of cells to capture and ingest foreign particles. Small
unicellular organisms such as free-living amoeba use this process to acquire food. In …

Since the discovery of lysosomes more than 70 years ago, much has been learned about
the functions of these organelles. Lysosomes were regarded as exclusively degradative …

Lysosomal storage diseases (LSDs) are a family of disorders that result from inherited gene
mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in …

Despite widespread distribution of LAMP1 and the heterogeneous nature of LAMP1-labeled
compartments, LAMP1 is routinely used as a lysosomal marker, and LAMP1-positive …

Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …

Lysosomes are dynamic organelles that receive and degrade macromolecules from the
secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Live-cell …

The endosomal sorting complex required for transport (ESCRT) protein machinery
comprises four complexes, ESCRT‐0, ESCRT‐I, ESCRT‐II and ESCRT‐III, that facilitate …

Lysosomes were once considered the end point of endocytosis, simply used for
macromolecule degradation. They are now recognized to be dynamic organelles, able to …

The endocytic delivery of macromolecules from the mammalian cell surface for degradation
by lysosomal acid hydrolases requires traffic through early endosomes to late endosomes …