Lysosome biogenesis: Regulation and functions
C Yang, X Wang - Journal of Cell Biology, 2021 - rupress.org
Lysosomes are degradation centers and signaling hubs in cells and play important roles in
cellular homeostasis, development, and aging. Changes in lysosome function are essential …
cellular homeostasis, development, and aging. Changes in lysosome function are essential …
Control of phagocytosis by microbial pathogens
E Uribe-Querol, C Rosales - Frontiers in immunology, 2017 - frontiersin.org
Phagocytosis is a fundamental process of cells to capture and ingest foreign particles. Small
unicellular organisms such as free-living amoeba use this process to acquire food. In …
unicellular organisms such as free-living amoeba use this process to acquire food. In …
Current methods to analyze lysosome morphology, positioning, motility and function
Since the discovery of lysosomes more than 70 years ago, much has been learned about
the functions of these organelles. Lysosomes were regarded as exclusively degradative …
the functions of these organelles. Lysosomes were regarded as exclusively degradative …
Lysosomal storage disorders: The cellular impact of lysosomal dysfunction
Lysosomal storage diseases (LSDs) are a family of disorders that result from inherited gene
mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in …
mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in …
Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons
Despite widespread distribution of LAMP1 and the heterogeneous nature of LAMP1-labeled
compartments, LAMP1 is routinely used as a lysosomal marker, and LAMP1-positive …
compartments, LAMP1 is routinely used as a lysosomal marker, and LAMP1-positive …
Nanoparticle entry into cells; the cell biology weak link
G Griffiths, J Gruenberg, M Marsh, J Wohlmann… - Advanced Drug Delivery …, 2022 - Elsevier
Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …
Lysosomes: fusion and function
Lysosomes are dynamic organelles that receive and degrade macromolecules from the
secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Live-cell …
secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Live-cell …
Multivesicular endosome biogenesis in the absence of ESCRTs
S Stuffers, C Sem Wegner, H Stenmark, A Brech - Traffic, 2009 - Wiley Online Library
The endosomal sorting complex required for transport (ESCRT) protein machinery
comprises four complexes, ESCRT‐0, ESCRT‐I, ESCRT‐II and ESCRT‐III, that facilitate …
comprises four complexes, ESCRT‐0, ESCRT‐I, ESCRT‐II and ESCRT‐III, that facilitate …
The biogenesis of lysosomes and lysosome-related organelles
JP Luzio, Y Hackmann… - Cold Spring …, 2014 - cshperspectives.cshlp.org
Lysosomes were once considered the end point of endocytosis, simply used for
macromolecule degradation. They are now recognized to be dynamic organelles, able to …
macromolecule degradation. They are now recognized to be dynamic organelles, able to …
Endolysosomes are the principal intracellular sites of acid hydrolase activity
NA Bright, LJ Davis, JP Luzio - Current Biology, 2016 - cell.com
The endocytic delivery of macromolecules from the mammalian cell surface for degradation
by lysosomal acid hydrolases requires traffic through early endosomes to late endosomes …
by lysosomal acid hydrolases requires traffic through early endosomes to late endosomes …