Imaging of anticancer drug action in single cells

MA Miller, R Weissleder - Nature Reviews Cancer, 2017 - nature.com
Imaging is widely used in anticancer drug development, typically for whole-body tracking of
labelled drugs to different organs or to assess drug efficacy through volumetric …

Recording the wild lives of immune cells

MJ Pittet, CS Garris, SP Arlauckas, R Weissleder - Science immunology, 2018 - science.org
Intravital microscopic imaging can uncover fundamental aspects of immune cell behavior in
real time in both healthy and pathological states. Here, we discuss approaches for single …

Cancer cell membrane-biomimetic nanoprobes with two-photon excitation and near-infrared emission for intravital tumor fluorescence imaging

Y Lv, M Liu, Y Zhang, X Wang, F Zhang, F Li, WE Bao… - ACS …, 2018 - ACS Publications
Biomimetic fluorescent nanoprobes capable of emitting near-infrared (NIR) fluorescence
(λmax≈ 720 nm) upon excitation of 800 nm light were developed. The key conjugated …

High flux passive imaging with single-photon sensors

A Ingle, A Velten, M Gupta - Proceedings of the IEEE/CVF …, 2019 - openaccess.thecvf.com
Single-photon avalanche diodes (SPADs) are an emerging technology with a unique
capability of capturing individual photons with high timing precision. SPADs are being used …

Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins

A Aouacheria, S Baghdiguian, HM Lamb… - Neurochemistry …, 2017 - Elsevier
The morphology of a population of mitochondria is the result of several interacting dynamical
phenomena, including fission, fusion, movement, elimination and biogenesis. Each of these …

Fluorescence anisotropy imaging in drug discovery

C Vinegoni, PF Feruglio, I Gryczynski… - Advanced drug delivery …, 2019 - Elsevier
Non-invasive measurement of drug-target engagement can provide critical insights in the
molecular pharmacology of small molecule drugs. Fluorescence polarization/fluorescence …

Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior

MA Miller, R Weissleder - Advanced drug delivery reviews, 2017 - Elsevier
Therapeutic nanoparticles (NPs) can deliver cytotoxic chemotherapeutics and other drugs
more safely and efficiently to patients; furthermore, selective delivery to target tissues can …

The modulo Radon transform and its inversion

A Bhandari, M Beckmann… - 2020 28th European …, 2021 - ieeexplore.ieee.org
In this paper, we introduce the Modulo Radon Transform (MRT) which is complemented by
an inversion algorithm. The MRT generalizes the conventional Radon Transform and is …

152-dB dynamic range with a large-area custom-technology single-photon avalanche diode

F Ceccarelli, G Acconcia, I Labanca… - IEEE Photonics …, 2018 - ieeexplore.ieee.org
In this letter, we demonstrate a dynamic range as high as 152 dB with a detection head
based on a single-photon avalanche diode (SPAD). This result has been attained by …

[HTML][HTML] Multi-exposure microscopic image fusion-based detail enhancement algorithm

H Singh, G Cristobal, G Bueno, S Blanco, S Singh… - Ultramicroscopy, 2022 - Elsevier
Traditional microscope imaging techniques are unable to retrieve the complete dynamic
range of a diatom species with complex silica-based cell walls and multi-scale patterns. In …