SWITCH deficient SUCROSE NONFERMENTING (SWI/SNF) class chromatin remodeling
complexes (CRCs) use the energy derived from ATP hydrolysis to facilitate access of …

Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

The aging process results in significant epigenetic changes at all levels of chromatin and
DNA organization. These include reduced global heterochromatin, nucleosome remodeling …

Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …

Posttranslational modifications of histone tails regulate chromatin structure and transcription.
Here we present global analyses of histone acetylation and histone H3 Lys 4 methylation …

Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …

Chromatin remodellers are specialized multi-protein machines that enable access to
nucleosomal DNA by altering the structure, composition and positioning of nucleosomes. All …

The association of genes with the nuclear pore complex (NPC) and nuclear transport factors
has been implicated in transcriptional regulation. We therefore examined the association of …

The sequence specificity of DNA-binding proteins is the primary mechanism by which the
cell recognizes genomic features. Here, we describe systematic determination of yeast …

Transcription factors (TFs) regulate the expression of genes through sequence-specific
interactions with DNA-binding sites. However, despite recent progress in identifying in vivo …