Sugar-based aggregation-induced emission luminogens: design, structures, and applications

Y Wang, J Nie, W Fang, L Yang, Q Hu, Z Wang… - Chemical …, 2020 - ACS Publications
Sugars are abundant natural sources existing in biological systems, and bioactive
saccharides have attracted much more attention in the field of biochemistry and …

Marine origin polysaccharides in drug delivery systems

MJ Cardoso, RR Costa, JF Mano - Marine drugs, 2016 - mdpi.com
Oceans are a vast source of natural substances. In them, we find various compounds with
wide biotechnological and biomedical applicabilities. The exploitation of the sea as a …

One-Step Synthesis of Water-Soluble MoS2 Quantum Dots via a Hydrothermal Method as a Fluorescent Probe for Hyaluronidase Detection

W Gu, Y Yan, C Zhang, C Ding… - ACS applied materials & …, 2016 - ACS Publications
In this work, a bottom-up strategy is developed to synthesize water-soluble molybdenum
disulfide quantum dots (MoS2 QDs) through a simple, one-step hydrothermal method using …

Bioengineered 3D brain tumor model to elucidate the effects of matrix stiffness on glioblastoma cell behavior using PEG-based hydrogels

C Wang, X Tong, F Yang - Molecular pharmaceutics, 2014 - ACS Publications
Glioblastoma (GBM) is the most common and aggressive form of primary brain tumor with a
median survival of 12–15 months, and the mechanisms underlying GBM tumor progression …

Tumor-targeting hyaluronic acid nanoparticles for photodynamic imaging and therapy

HY Yoon, H Koo, KY Choi, SJ Lee, K Kim, IC Kwon… - Biomaterials, 2012 - Elsevier
Tumor-targeted imaging and therapy have been the challenging issue in the clinical field.
Herein, we report tumor-targeting hyaluronic acid nanoparticles (HANPs) as the carrier of …

Extracellular matrix and heart development

M Lockhart, E Wirrig, A Phelps… - Birth Defects Research …, 2011 - Wiley Online Library
The extracellular matrix (ECM) of the developing heart contains numerous molecules that
form a dynamic environment that plays an active and crucial role in the regulation of cellular …

Deregulated hyaluronan metabolism in the tumor microenvironment drives cancer inflammation and tumor-associated immune suppression

W Donelan, PR Dominguez-Gutierrez… - Frontiers in …, 2022 - frontiersin.org
Hyaluronan (HA) is known to be a prominent component of the extracellular matrix in tumors,
and many solid cancers are characterized by aberrant HA metabolism resulting in increased …

Key matrix remodeling enzymes: functions and targeting in cancer

Z Piperigkou, K Kyriakopoulou, C Koutsakis… - Cancers, 2021 - mdpi.com
Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …

Immunotherapy against several tumors, such as lung cancer, including nsclc

T Weinschenk, S Walter, J Fritsche… - US Patent App. 14 …, 2016 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52460698&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Emerging roles for hyaluronidase in cancer metastasis and therapy

CO McAtee, JJ Barycki, MA Simpson - Advances in cancer research, 2014 - Elsevier
Hyaluronidases are a family of five human enzymes that have been differentially implicated
in the progression of many solid tumor types, both clinically and in functional studies …