Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Eosinophils are evolutionarily conserved, pleotropic cells that display key effector functions
in allergic diseases, such as asthma. Nonetheless, eosinophils infiltrate multiple tumours …

Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Eosinophils are bone marrow‐derived granulocytes and are found in low numbers in the
peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the …

Prolonged low-grade inflammation or smoldering inflammation is a hallmark of a cancer.
Eosinophils are components of the immune microenvironment that modulates tumor …

Immunotherapy has emerged as a promising approach to treat cancer, however, its efficacy
in highly malignant brain-tumors, glioblastomas (GBM), is limited. Here, we generate distinct …

Post-translational modification of chemokines mediated by the dipeptidyl peptidase DPP4
(CD26) has been shown to negatively regulate lymphocyte trafficking, and its inhibition …

Immunotherapies targeting T lymphocytes are revolutionizing cancer therapy but only
benefit a subset of patients, especially in colorectal cancer. Thus, additional insight into the …

The function of T cells is critically dependent on their ability to generate metabolic building
blocks to fulfil energy demands for proliferation and consecutive differentiation into various T …

The tumor microenvironment (TME) of diverse cancer types is often characterized by high
levels of infiltrating myeloid cells including monocytes, macrophages, dendritic cells, and …