Sharp wave ripples (SPW‐Rs) represent the most synchronous population pattern in the
mammalian brain. Their excitatory output affects a wide area of the cortex and several …

Epilepsy has been historically seen as a functional brain disorder associated with excessive
synchronization of large neuronal populations leading to a hypersynchronous state. Recent …

Local field potentials (LFPs) are of growing importance in neurophysiological investigations.
LFPs supplement action potential recordings by indexing activity relevant to EEG …

The discovery that electroencephalography (EEG) contains useful information at frequencies
above the traditional 80Hz limit has had a profound impact on our understanding of brain …

In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to
develop new pharmacological treatments, in vivo animal models that present features …

Sharp-wave ripples (SPW-Rs) in the hippocampus are implied in memory consolidation, as
shown by observational and interventional experiments. However, the mechanism of their …

High‐frequency oscillations (HFO s) are a type of brain activity that is recorded from brain
regions capable of generating seizures. Because of the close association of HFO s with …

Fundamental work on the mechanisms leading to focal epileptic discharges in mesial
temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial …

Hippocampal sharp waves (SPWs) and associated fast (“ripple”) oscillations (SPW-Rs) in
the CA1 region are among the most synchronous physiological patterns in the mammalian …

Introduction Neurostimulation applied from deep brain stimulation (DBS) electrodes is an
effective therapeutic intervention in patients suffering from intractable drug-resistant epilepsy …