Abstract ENPP1 (ecto-nucleotide pyrophosphatase/phosphodiesterase) participates in the
hydrolysis of different purine nucleotides in an array of physiologic processes. However …

NETs are chromatin-derived webs extruded from neutrophils as a result of either infection or
sterile stimulation using chemicals, cytokines, or microbes. In addition to the classical role …

Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) expression correlates with
poor prognosis in many cancers, and we previously discovered that ENPP1 is the dominant …

Pattern-recognition receptors (PRRs) are critical to recognizing endogenous and exogenous
threats to mount a protective proinflammatory innate immune response. PRRs may be …

Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is a type II transmembrane
glycoprotein expressed in many tissues. High expression levels of ENPP1 have been …

Background Dysregulated ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP)
family occurs in metabolic reprogramming pathological processes. Nonetheless, the …

The clinical efficacy of surgery, radiotherapy, and chemotherapy for cancer is usually limited
by the deterioration of tumor microenvironment (TME). Neutrophil extracellular traps (NETs) …

Advances in melanoma research have unveiled critical insights into its genetic and
molecular landscape, leading to significant therapeutic innovations. This review explores the …

Tumor immunity is a growing field of research that involves immune cells within the tumor
microenvironment. Neutrophil extracellular traps (NETs) are neutrophil-derived extracellular …

Cytosolic double-stranded DNA (dsDNA) is frequently accumulated in cancer cells due to
chromosomal instability or exogenous stimulation. Cyclic GMP-AMP synthase (cGAS) acts …