This paper will review the methods that have been advanced for the estimation of
parameters of models quantifying the population characteristics of the kinetic behavior of …

Validation of bioanalytical methods used to generate data for pharmacokinetic and
bioavailability studies is approached by a variety of techniques and is subject to many …

According to linear pharmacokinetics, the time course of plasma concentration of a drug, C
p, is expressed by a sum of exponential functions, C p= ε i= 1 nai C_p= ∑ i= 1^ n a_i e^-b_i …

We propose a model of drug pharmacodynamic response that when integrated with a
pharmacokinetic model allows characterization of the temporal aspects of …

METFORMIN KINETICS IN HEALTHY SUBJECTS AND IN PATIENTS WITH DIABETES
MELLITUS Page 1 Br. J. clin. Pharmac. (1981), 12, 235-246 METFORMIN KINETICS IN …

The absolute bioavailability of orally administered caffeine was investigated in 10 healthy
adult male volunteers, aged 18.8 to 30.0 years. The subjects were administered a 5 mg/kg …

Bioanalytical method validation is the process used to establish that a quantitative analytical
method is suitable for biomedical applications. Reassurances as to the quality of the method …

Tranexamic acid 1 g was given intravenously to three healthy volunteers. Plasma
concentrations decayed in three monoexponential phases. Most elimination took place …

In pharmacokinetic data analysis, it is frequently necessary to select the number of
exponential terms in a polyexponential expression used to describe the concentration-time …

The pharmacokinetics of diclofenac were examined following single rapid intravenous
injection and also following single oral doses to healthy female volunteers. After intravenous …