Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2

M Gheblawi, K Wang, A Viveiros, Q Nguyen… - Circulation …, 2020 - Am Heart Assoc
ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that
revolve around its trivalent function: a negative regulator of the renin-angiotensin system …

Organ‐protective effect of angiotensin‐converting enzyme 2 and its effect on the prognosis of COVID‐19

H Cheng, Y Wang, GQ Wang - Journal of medical virology, 2020 - Wiley Online Library
This article reviews the correlation between angiotensin‐converting enzyme 2 (ACE2) and
severe risk factors for coronavirus disease 2019 (COVID‐19) and the possible mechanisms …

[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Interaction of SARS-CoV-2 and other coronavirus with ACE (angiotensin-converting enzyme)-2 as their main receptor: therapeutic implications

AM Davidson, J Wysocki, D Batlle - Hypertension, 2020 - Am Heart Assoc
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 originated from Wuhan,
China, in December 2019 and rapidly spread to other areas worldwide. Since then …

The vasoprotective axes of the renin-angiotensin system: physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases

XC Li, J Zhang, JL Zhuo - Pharmacological research, 2017 - Elsevier
The renin-angiotensin system (RAS) is undisputedly one of the most prominent endocrine
(tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) vasoactive …

Diabetic nephropathy: an insight into molecular mechanisms and emerging therapies

AM Warren, ST Knudsen, ME Cooper - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Diabetic kidney disease (DKD) is a major cause of morbidity and mortality in
diabetes and is the most common cause of proteinuric and non-proteinuric forms of end …

Alveolar epithelial cell type II as main target of SARS-CoV-2 virus and COVID-19 development via NF-Kb pathway deregulation: A physio-pathological theory

M Carcaterra, C Caruso - Medical hypotheses, 2021 - Elsevier
Abstract The Corona Virus Disease (COVID-19) pandemic caused by Severe Acute
Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) requires a rapid solution and global …

Angiotensin‐converting enzyme 2 (ACE2) is a key modulator of the renin angiotensin system in health and disease

C Tikellis, MC Thomas - International journal of peptides, 2012 - Wiley Online Library
Angiotensin‐converting enzyme 2 (ACE2) shares some homology with angiotensin‐
converting enzyme (ACE) but is not inhibited by ACE inhibitors. The main role of ACE2 is the …

Variants in ACE2; potential influences on virus infection and COVID-19 severity

B Bakhshandeh, SG Sorboni, AR Javanmard… - Infection, Genetics and …, 2021 - Elsevier
The third pandemic of coronavirus infection, called COVID-19 disease, was first detected in
November 2019th. Various determinants of disease progression such as age, sex, virus …

Potential role of ACE2 in coronavirus disease 2019 (COVID-19) prevention and management

M Liu, T Wang, Y Zhou, Y Zhao, Y Zhang… - Journal of translational …, 2020 - degruyter.com
COVID-19 is the current public health threat all over the world. Unfortunately, there is no
specific prevention and treatment strategy for this disease. We aim to explore the potential …