Structural diversity, characterization and toxicology of microcystins

N Bouaïcha, CO Miles, DG Beach, Z Labidi, A Djabri… - Toxins, 2019 - mdpi.com
Hepatotoxic microcystins (MCs) are the most widespread class of cyanotoxins and the one
that has most often been implicated in cyanobacterial toxicosis. One of the main challenges …

Occurrence and toxicity of microcystin congeners other than MC-LR and MC-RR: A review

L Díez-Quijada, AI Prieto, R Guzmán-Guillén… - Food and chemical …, 2019 - Elsevier
The occurrence of cyanobacterial toxins is being increasingly reported. This is a reason for
concern as they can induce toxic effects both in humans and in the environment. Among …

Cyanobacterial toxins as allelochemicals with potential applications as algaecides, herbicides and insecticides

JP Berry, M Gantar, MH Perez, G Berry, FG Noriega - Marine drugs, 2008 - mdpi.com
Cyanobacteria (“blue-green algae”) from marine and freshwater habitats are known to
produce a diverse array of toxic or otherwise bioactive metabolites. However, the functional …

Increasing Oxygen Radicals and Water Temperature Select for Toxic Microcystis sp

C Dziallas, HP Grossart - PLoS One, 2011 - journals.plos.org
Pronounced rises in frequency of toxic cyanobacterial blooms are recently observed
worldwide, particularly when temperatures increase. Different strains of cyanobacterial …

Microcystins: Biogenesis, toxicity, analysis, and control

CM Schreidah, K Ratnayake, K Senarath… - Chemical research in …, 2020 - ACS Publications
Microcystins are cyclic peptide toxins formed by cyanobacteria. These toxins are recognized
for their association with algal blooms, posing a significant threat to ecosystems and drinking …

Aerucyclamides A and B: Isolation and Synthesis of Toxic Ribosomal Heterocyclic Peptides from the Cyanobacterium Microcystis aeruginosa PCC 7806

C Portmann, JF Blom, K Gademann… - Journal of natural …, 2008 - ACS Publications
Two new modified hexacyclopeptides, aerucyclamides A and B, were isolated from the toxic
freshwater cyanobacterium Microcystis aeruginosa PCC 7806. The constitution was …

Comparative cellular toxicity of hydrophilic and hydrophobic microcystins on Caco-2 cells

PSM Vesterkvist, JO Misiorek, LEM Spoof, DM Toivola… - Toxins, 2012 - mdpi.com
Microcystins (MC), cyanobacterial peptide hepatotoxins, comprise more than 100 different
variants. They are rather polar molecules but some variants contain hydrophobic amino acid …

Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis

Y Chen, J Wang, Q Zhang, Z Xiang, D Li, X Han - Environmental Pollution, 2017 - Elsevier
Microcystin-leucine arginine (MC-LR) causes testicular inflammation and hinders
spermatogenesis. However, the molecular mechanisms underlying the immune responses …

Microcystin–leucine–arginine causes blood–testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8

Y Chen, J Wang, C Pan, D Li, X Han - Cellular and Molecular Life Sciences, 2018 - Springer
Abstract Microcystin–leucine–arginine (MC-LR) can cause male reproductive disorders.
However, the underlying mechanisms are not yet fully understood. In this study, we aimed to …

Multiple Toxin Production in the Cyanobacterium Microcystis: Isolation of the Toxic Protease Inhibitor Cyanopeptolin 1020

K Gademann, C Portmann, JF Blom… - Journal of natural …, 2010 - ACS Publications
The isolation and structure of cyanopeptolin 1020 (hexanoic acid-Glu-N [-O-Thr-Arg-Ahp-
Phe-N-Me-Tyr-Val-]) from a Microcystis strain is reported. Very potent picomolar trypsin …