Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

SA Polyzos, J Kountouras, CS Mantzoros - Metabolism, 2019 - Elsevier
The obesity epidemic is closely associated with the rising prevalence and severity of
nonalcoholic fatty liver disease (NAFLD): obesity has been linked not only with simple …

Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease

L Castera, M Friedrich-Rust, R Loomba - Gastroenterology, 2019 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is estimated to afflict approximately 1 billion
individuals worldwide. In a subset of NAFLD patients, who have the progressive form of …

Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers

E Vilar-Gomez, N Chalasani - Journal of hepatology, 2018 - Elsevier
The correct identification of patients at increased risk of non-alcoholic steatohepatitis
(NASH) and advanced fibrosis is a critical step in the assessment of non-alcoholic fatty liver …

[HTML][HTML] Enhanced liver fibrosis test for the non-invasive diagnosis of fibrosis in patients with NAFLD: a systematic review and meta-analysis

Y Vali, J Lee, J Boursier, R Spijker, J Löffler… - Journal of …, 2020 - Elsevier
Background & Aims The enhanced liver fibrosis (ELF) test has been proposed for the non-
invasive assessment of advanced fibrosis in patients with non-alcoholic fatty liver disease …

[PDF][PDF] Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis

ZM Younossi, R Loomba, QM Anstee, ME Rinella… - …, 2018 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a spectrum comprised of isolated steatosis,
nonalcoholic steatohepatitis (NASH), advanced fibrosis, and cirrhosis. The majority of …

Pathophysiology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

V Manne, P Handa, KV Kowdley - Clinics in liver disease, 2018 - liver.theclinics.com
The pathophysiology of NAFL and NASH is complex and numerous intermediaries are
involved. Each year brings new and exciting developments as pieces of the …

Epidemiology and natural history of non-alcoholic fatty liver disease

Y Fazel, AB Koenig, M Sayiner, ZD Goodman… - Metabolism, 2016 - Elsevier
Non-alcoholic steatohepatitis (NASH) is part of the spectrum of non-alcoholic fatty liver
disease (NAFLD) that leads to progressive liver disease and presents a growing challenge …

Hepatocyte TAZ/WWTR1 promotes inflammation and fibrosis in nonalcoholic steatohepatitis

X Wang, ZE Zheng, JM Caviglia, KE Corey, TM Herfel… - Cell metabolism, 2016 - cell.com
Nonalcoholic steatohepatitis (NASH) is a leading cause of liver disease worldwide.
However, the molecular basis of how benign steatosis progresses to NASH is incompletely …

Pathophysiology and mechanisms of nonalcoholic fatty liver disease

JT Haas, S Francque, B Staels - Annual review of physiology, 2016 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver disorders
characterized by abnormal hepatic fat accumulation, inflammation, and hepatocyte …

Adipokines in nonalcoholic fatty liver disease

SA Polyzos, J Kountouras, CS Mantzoros - Metabolism, 2016 - Elsevier
Since the discovery of adipose tissue as a higly active endocrine tissue, adipokines,
peptides produced by adipose tissue and exerting autocrine, paracrine and endocrine …