Hemispheric asymmetries represent one of the major organizational principles in vertebrate
neurobiology, but their molecular determinants are not well understood. For handedness …

Changing serotonin (5-hydroxytryptamine, 5-HT) brain levels during critical periods in
development has long-lasting effects on brain function, particularly on later …

Novel hypotheses suggest that antidepressants, such as the selective serotonin reuptake
inhibitor fluoxetine, induce neuronal structural plasticity, resembling that of the juvenile …

Escalated or abnormal aggression induced by early adverse experiences is a growing issue
of social concern and urges the development of effective treatment strategies. Here we …

The non-cell autonomous transfer of OTX2 homeoprotein transcription factor into juvenile
mouse cerebral cortex regulates parvalbumin interneuron maturation and critical period …

Major depressive disorder (MDD) is a devastating mental illness and the leading cause of
disability worldwide. Previous studies have suggested that synaptic plasticity in the …

There has been a growing interest in the potential for plasticity-inducing pharmacological
interventions to enhance post-stroke recovery. One group of drugs that continues to garner a …

The burgeoning field of neuroepigenetics has introduced chromatin modification as an
important interface between experience and brain function. For example, epigenetic …

The scarce functional recovery of the adult CNS following injuries or diseases is largely due
to its reduced potential for plasticity, the ability to reorganize neural connections as a …

The capability of the brain to change functionally in response to sensory experience is most
active during early stages of development but it decreases later in life when major …