Currently, the demand for more reliable drug screening devices has made scientists and
researchers develop novel potential approaches to offer an alternative to animal studies …

Spontaneous preterm birth (PTB) and preterm pre-labor rupture of the membranes (pPROM)
are major pregnancy complications. Although PTB and pPROM have common etiologies …

Objectives: To improve preclinical drug testing during pregnancy, we developed multiple
microfluidic organ-on-chip (OOC) devices that represent the structure, functions, and …

Preterm birth (PTB;< 37 weeks of gestation) impacts∼ 11% of all pregnancies and
contributes to 1 million neonatal deaths worldwide annually. An understanding of the feto …

Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to
change the efficiency, effectiveness, and costs of the drug discovery process; to advance …

One of the leading challenges facing the pharmaceutical industry today is the 'high attrition
rate problem', with a large number of drug candidates being abandoned before reaching the …

During the last decade, organs-on-chips or organoids microphysiological analysis platforms
(MAP) have garnered attention in the practical applications of disease models, drug …

The placenta and fetal membrane act as a protective barrier throughout pregnancy while
maintaining communication and nutrient exchange between the baby and the mother …

Remodeling of extracellular matrix in the womb facilitates the dramatic morphogenesis of
maternal and placental tissues necessary to support fetal development. In addition to …

The female reproductive system comprises the internal and external genitalia, which
communicate through intricate endocrine pathways. Besides secreting hormones that …