Advanced glycation end products (AGEs) are a heterogeneous, complex group of
compounds that are formed when reducing sugar reacts in a non-enzymatic way with amino …

The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …

Malnutrition is common among older persons, with important consequences increasing
frailty and morbidity and reducing health expectancy. On the contrary, calorie restriction (CR …

Biological ageing is generally accompanied by a gradual loss of cellular functions and
physiological integrity of organ systems, the consequential enhancement of vulnerability …

Dry eye disease is a prevalent eye disorder that in particular affects the elderly population.
One of the major causes of dry eye, meibomian gland dysfunction (MGD), shows increased …

Circadian rhythms permeate mammalian biology. They are manifested in the temporal
organisation of behavioural, physiological, cellular and neuronal processes. Whereas it has …

GH/insulin/IGF-1 signaling is a vital pathway eg in the regulation of protein synthesis and
glucose metabolism. However, mouse dwarf strains which exhibit reduced GH secretion and …

Several epidemiologic studies have implicated visceral fat as a major risk factor for insulin
resistance, type 2 diabetes mellitus, cardiovascular disease, stroke, metabolic syndrome …

Aging affects a myriad of genetic, biochemical, and metabolic processes, and efforts to
understand the underlying molecular basis of aging are often thwarted by the complexity of …

Aging is defined as a normal decline in survival with advancing age; however, the recent
researches have showed that physiological functions of the body change during the aging …