There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …

Although there has been impressive progress in the elucidation of the genetic and molecular
basis of cystic fibrosis (CF), the pathogenesis of CF lung disease remains obscure. The …

The concept that adenine and uridine nucleotides function as extracellular signaling
molecules has been markedly expanded in the last decade. At least 15 nucleotide-activated …

Cystic fibrosis transmembrane conductance regulator (CFTR), a Cl−-selective ion channel,
is a prototypic member of the ATP-binding cassette transporter superfamily that is expressed …

Epithelial salt and water secretion serves a variety of functions in different organ systems,
such as the airways, intestines, pancreas, and salivary glands. In cystic fibrosis (CF), the …

The charge of this invited review is to present a convincing case for the fact that cells release
their ATP for physiological reasons. Many of our “purinergic” colleagues as well as …

The adenylyl cyclases are variously regulated by G protein subunits, a number of
serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations …

Mammalian airways normally regulate the volume of a thin liquid layer, the periciliary liquid
(PCL), to facilitate the mucus clearance component of lung defense. Studies under standard …

Epithelial tight junctions (TJs) provide an important route for passive electrolyte transport
across airway epithelium and provide a barrier to the migration of toxic materials from the …

Corneal transparency is dependent on regulation of the hydration of the corneal stroma.
Water is driven into the cornea across the epithelial and endothelial cell layers by the …