Mapping a genetic perturbation to a change in phenotype is at the core of biological
research. Advances in microscopy have transformed these studies, but they have largely …

Microscopy is a powerful tool for characterizing complex cellular phenotypes, but linking
these phenotypes to genotype or RNA expression at scale remains challenging. Here, we …

Unraveling the genetic and epigenetic determinants of phenotypes is critical for
understanding and re-engineering biology and would benefit from improved methods to …

The development and clinical implementation of personalized medicine crucially depends
on the availability of high-quality human biosamples; animal models, although capable of …

Adoptive T cell therapies rely on the production of T cells with an antigen receptor that
directs their specificity toward tumor-specific antigens. Methods for identifying relevant T cell …

The genetic alterations contributing to migration proficiency, a phenotypic hallmark of
metastatic cells required for colonizing distant organs, remain poorly defined. Here, we used …

Single‐cell RNA sequencing (scRNA‐seq) has emerged as a powerful tool for profiling gene
expression of distinct cell populations at the single‐cell level. However, the information of …

The qkI gene encodes a family of RNA binding proteins alternatively spliced at its 3′ end,
giving rise to three major spliced isoforms: QKI-5, QKI-6 and QKI-7. Their expression is …

Single-cell analysis has become an essential tool in modern biological research, providing
unprecedented insights into cellular behavior and heterogeneity. By examining individual …

ABSTRACT USP16 (also known as UBP-M) has emerged as a histone H2AK119
deubiquitylase (DUB) implicated in the regulation of chromatin-associated processes and …